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A Leisurely Look at Genomics Research Using Microarrays-Fall 2009
FRS 001T -- Sec. 008 -- (1 unit) -- CRN 25083 -- Tue 5:10-6:00 PM--25 Wellman
Course Description (TRC)
Instructor: Danh Nguyen, Ph.D.
Office: MS1C RM 149 (direction/map)
Office hours: By appointment.
Email: ucdnguyen@ucdavis.edu
Syllabus [PDF]
For Week 1: Genes and gene expression basics.
Read "genetics 101"
(Sections: a. From gene to proteome, b. What we've learned so far, c. The next step: functional genomics.
Please skip the section on "How is genome sequencing done?"). Read pages 3-6 of handout "The Answer in a
Nut Schell: Genes, Proteins, and the Meaning of Life" (chapter 1 from The Human Genome: A User's
Guide by R.S. Hawley and C.A. Mori): pages
3
4
5
6.
For Week 2: From genes to genomes.
Introduction to basics continued. Transcriptomics: measuring "all" messenger RNA. Genomics research.
Diagram of cDNA micorarray process.
For next week, read
description of microarray from NHGRI (National Human Genome Research Institute).
Also read Times article
"DNA Microarrays: The workhorse of genomic medicine" by Unmesh Kher (01/2001),
For Week 3: More on microarray experimental procedure, gene vs. genomics approach.
Assigment 1 (Due week 3):
[MS Word format]--
[PDF format]
Handout 1:
[MS Word format] --
[PDF format]
Handout 2:
[MS Word format]
[PDF format]
Week 4: Application 1 - Leukemia classification.
Reading materials for week 3: Science article.
[PDF format]
Week 5:
Application 2: "Discovering" (investigating) subtypes of B-cell lymphoma.
Reading materials: Nature article.
[PDF format]
Homework 2:
[MS Word format]
Review: cDNA microarray:--Cartoon animation of the cDNA microarray process - we did this in class
in week 3.
cDNA animation.
Week 6: Application 3: Infectious diseases, Influenza (flu), SARS, Bird Flu &
microarrays.
Group/individual assignment:
[MS Word format]
Reading materials for week 5:
Article 1:
[PDF format]
Article 2:
[PDF format]
Article 3:
[PDF format]
Reading materials for week 7:
Article 4:
[PDF format]
Links: Access Excellence Graphics Gallery
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