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A Leisurely Look at Genomic Research Using Microarrays-Fall 2005 FRS 001T -- Sec. 017 -- (1 unit) -- CRN 53585 -- W 5:10-6:00 PM--25 Wellman Course Description Instructor: Danh Nguyen, Ph.D. Office: MS1C RM 143 Office hours: By appointment. Email: ucdnguyen@ucdavis.edu Syllabus [PDF] Week 1: Genes and gene expression basics. Read "genetics 101" (Sections: a. From gene to proteome, b. What we've learned so far, c. The next step: functional genomics. Skip the section on "How is genome sequencing done?"). Read pages 3-6 of handout "The Answer in a Nut Schell: Genes, Proteins, and the Meaning of Life" (chapter 1 from The Human Genome: A User's Guide by R.S. Hawley and C.A. Mori): pages 3   4   5   6. Week 2: From genes to genomes. Introduction to basics continued. Transcriptomics: measuring "all" messenger RNA. Genomics research. Diagram of cDNA micorarray process. For next week, read description of microarray from NHGRI (National Human Genome Research Institute). Also read Times article "DNA Microarrays: The workhorse of genomic medicine" by Unmesh Kher (01/2001), Week 2 handout: [MS Word format] -- [PDF format] Assigment 1 (Due week 3 Wed 10/19): [MS Word format]-- [PDF format] Week 3: Microarray experimental procedure and interpreting microarray results. Week 3 handout: [MS Word format]-- [PDF format] Week 4: Application 1: Leukemia classification. Reading materials for week 4: Science article. [PDF format] Week 5: Application 2: "Discovering" (investigating) subtypes of B-cell lymphoma. Reading materials for week 5: Nature article. [PDF format] Reading guide/questions for discussion: [MS Word format]-- [PDF format] Week 6 & 7: Application 3: Infectious diseases, SARS, Bird Flu & microarrays. Group/individual assignment: [MS Word format]-- [PDF format] Reading materials for week 6: Article 1: [PDF format] Article 2: [PDF format] Article 3: [PDF format] Reading materials for week 7: Article 4: [PDF format] Week 8: holiday Week 9: Basic principles in the analysis of genomics data Discussion topics and final assignment/report: [MS Word format]-- [PDF format] Course Grade: [MS Word format]-- [PDF format] Links: Access Excellence Graphics Gallery